Croma Pharma Products: Complete Guide for Aesthetic Practices

Key Takeaways

• Three core product platforms: Saypha HA fillers, PhilArt polynucleotide skin boosters, and Juveleus/juvenus-style PN gels for bio-revitalization.
• European leader in HA manufacturing: Croma-Pharma is an Austrian, family-owned company that produces millions of HA syringes annually and distributes minimally invasive aesthetic products to 70+ countries.
• Regenerative focus: PhilArt and Juveleus products use highly purified polynucleotides to stimulate collagen, hydration, and tissue repair, supporting long-term skin-quality improvement rather than just short-term filling.
• Typical pricing bands: HA and polynucleotide injectables in this category commonly retail around $600–$1,500 per session, depending on product choice, geography, and number of syringes/vials used.
• Portrait Care can help: Tiered pricing and bulk discounts, delivered through a centralized ordering experience, help practices source Croma Pharma products and other aesthetic brands profitably while keeping inventory and margins under control.

About Croma Pharma

Croma-Pharma GmbH is an Austrian, family-founded pharmaceutical company that has specialized in minimally invasive aesthetic medicine after divesting its ophthalmology and orthopedics divisions in 2014. 

Founded in 1976 by pharmacist Gerhard Prinz and now managed by his sons, Croma has grown into a global hyaluronic acid expert, producing nearly six million HA syringes annually and distributing to more than 70 countries through affiliates and strategic partners. The company's headquarters and manufacturing remain in Leobendorf near Vienna, where it focuses on HA fillers, PDO threads, PRP systems, and personalized skincare technologies for aesthetic practices.

Croma Pharma At A Glance

• Parent company: Croma-Pharma GmbH, privately owned and family-led since 1976.
• Headquarters: Leobendorf, Austria, with around a dozen international offices across Europe, Brazil, and other key markets.
• Core aesthetic products: Saypha HA fillers, PhilArt polynucleotide skin boosters, and Juveleus/juvenus-style regenerative injectables and PRP systems.
• Strategic focus: Minimally invasive aesthetics, including injectables, threads, and skin-regeneration technologies backed by in-house manufacturing and quality control.

What Is Croma Pharma Known For?

Croma is best known as a leading European processor of hyaluronic acid, leveraging high-volume syringe production and tight quality standards to deliver consistent, CE-marked filler products. The company has built its aesthetic reputation around natural-looking outcomes, skin-quality improvement, and regenerative approaches such as polynucleotide-based biostimulators and PRP systems, rather than purely volumizing fillers.

What Brands Does Croma Own?

Within aesthetics, Croma's key branded lines include the Saypha family of HA fillers, a dedicated PhilArt portfolio of polynucleotide skin boosters, and a regenerative platform that provides for Juveleus/juvenus-style polynucleotide gels and PRP technologies marketed in core geographies. Outside injectables, Croma also offers PDO lifting threads and personalized skincare technologies, positioning the company as a full-spectrum minimally invasive aesthetics partner for clinics seeking a mix of fillers, skin boosters, and regenerative treatments.

Croma Aesthetics Products List

Croma's aesthetic lineup spans three main categories: HA fillers for structure and contour, polynucleotide-based skin boosters for regeneration, and adjunct regenerative platforms such as Juvenus/Juveleus and PRP to improve texture and hydration. Understanding each bucket enables clinics to match products to patient needs—whether that is line correction, subtle volumization, or full-skin bio-revitalization.

1. Injectable HA Fillers: Saypha

Saypha (formerly marketed as Princess in many markets) is Croma's flagship hyaluronic acid filler line, produced from non-animal HA and available in multiple viscosities and lidocaine versions. The core sub-brands include Saypha RICH (skin hydration/mesotherapy), Saypha FILLER (moderate wrinkles and folds), Saypha VOLUME (deep volume restoration), and high-density variants like Saypha VOLUME Plus for structural contouring in cheeks, chin, and jawline.

Key characteristics:

• Technology: Non-animal, crosslinked HA designed for biocompatibility and smooth integration into tissues, with specific rheology tuned per indication.
• Indications: Treatment of fine lines, nasolabial folds, marionette lines, lip augmentation, midface volume loss, and contouring, depending on product selection.
• Duration: Results often last 6–12 months or longer, depending on product, area, and metabolism, broadly in line with other HA fillers on the market.
• Patient experience: Lidocaine-containing versions improve comfort during injection, and lower-viscosity formulations such as Saypha RICH act more like skin boosters than traditional volumizing fillers.

Typical patient pricing in the U.S. for HA fillers similar to Saypha generally ranges from about $600 to $1,200 per 1 mL syringe, depending on geography, injector expertise, and treatment zone.

2. Regenerative Injectables: PhilArt

PhilArt is Croma's polynucleotide-based regenerative portfolio, using highly purified PNs derived from salmon DNA to stimulate skin and tissue regeneration rather than simply filling lines. These products act as biostimulators: they support fibroblast activity, collagen synthesis, extracellular-matrix remodeling, and intense hydration through PN-HPT (Highly Purified Technology) formulations.

Key characteristics:

• Technology: Polynucleotides with hydrophilic and antioxidant properties that bind water, improve elasticity, and promote healthy cell turnover in the dermis.
• Indications: Early signs of aging, fine lines, dullness, texture irregularities, and scars (including acne scars) on the face, neck, décolletage, and hands, with product variants targeted to specific skin types and regions.
• Results: Patients typically see progressive improvement in hydration, firmness, and texture over a series of sessions, aligning with the broader class of regenerative skin boosters.

Pricing for polynucleotide skin boosters varies by clinic. Still, in markets where they are widely adopted, treatment plans often command a premium over traditional mesotherapy due to product cost and protocol-based series, sitting broadly in the mid-to-high range of injectable skin-quality treatments.

3. Regenerative Skin Boosters: Juveleus / Juvenus

Juveleus/juvenus-style products under the Croma umbrella reference polynucleotide gels designed for bio-revitalization rather than bulk volumization. These injectables use polymerized polynucleotides with strong water-binding capacity to increase dermal hydration and support collagen synthesis, with additional antioxidant benefits.

Key characteristics:

• Technology: PDRN-based or PN-based hydrophilic gels that fill interstitial spaces in skin and connective tissue, improving elasticity and smoothing fine wrinkles.
• Indications: Light-to-moderate wrinkles, early volume loss, skin laxity, and minor scarring, particularly in photo-damaged areas.
• Results: Improved plumpness, hydration, and texture over time, making them suitable for patients seeking subtle but global skin enhancement rather than dramatic contour changes.

These products help clinics expand beyond classic HA fillers into regenerative protocols that can be combined with other modalities such as PRP or energy-based treatments for comprehensive skin restoration.

Croma Aesthetics Products Price List: Wholesale vs. Retail

Wholesale pricing for Croma products varies by geography, distributor, and volume commitments, but practices can map economics using general filler-market benchmarks.

• Wholesale: For HA fillers comparable to Saypha, clinics often pay meaningfully below the typical U.S. retail range of $600–$1,200 per syringe, with per-syringe acquisition costs decreasing as volume and tiered purchasing agreements increase.
• Retail: Patients generally see pricing in line with other premium HA fillers and advanced skin boosters—approximately $600–$1,500 per session, depending on the product, region, and number of syringes or vials used.

The spread between wholesale and retail is what determines per-treatment margins, making supplier relationships and tiered pricing as necessary for Croma-based protocols as for any other filler or biostimulator line.

Are Croma Aesthetics Products Approved?

Croma's Saypha fillers are CE-marked medical devices in Europe, with multiple formulations (RICH, FILLER, VOLUME, VOLUME PLUS, with and without lidocaine) manufactured under strict quality standards from non-animal HA. PhilArt and related polynucleotide products are also marketed as CE-marked devices or injectables in relevant markets, with clinical positioning as regenerative skin boosters rather than classic volume fillers.

Regulatory status can differ by country, so clinics must confirm local approvals, device classifications, and labeling before introducing these products to their service menus, particularly in markets such as the United States, where distribution and clearances may be more limited or routed through partners.

How Long Do Croma Aesthetic Results Last?

• Saypha fillers: Generally deliver visible improvement for around 6–12 months, similar to other crosslinked HA fillers, with deeper volumizing products potentially lasting toward the upper end of that range.
• PhilArt and polynucleotide boosters: Produce progressive improvements over a treatment series, with benefits in hydration, elasticity, and texture that can persist several months after the last session, though maintenance protocols vary by practitioner.
• Juveleus/juvenus-style PN gels: Provide bio-revitalization effects and hydration that can last many months but typically require periodic maintenance treatments to sustain optimal results.

Actual duration depends heavily on patient factors, including metabolism, lifestyle, treatment area, and whether therapies are combined with adjunct skincare or device-based treatments.

Croma Aesthetics Reviews: Pros, Cons, And Best Fit

Advantages of Croma products include a strong HA manufacturing pedigree, a comprehensive Saypha range, and a growing regenerative portfolio with polynucleotide and PRP-based solutions that align with demand for skin-quality-focused treatments. Clinics benefit from CE-marked quality, European production, and formulations that cover everything from fine lines and hydration to deep volumization and regenerative protocols, allowing tailored treatment plans.

Limitations can include greater variability in brand recognition compared with household names like JUVÉDERM or Restylane in some markets, as well as the need to educate patients about polynucleotide-based treatments and set expectations for gradual, regenerative results. Regulatory status and distribution may also limit direct access in certain countries, requiring practices to work with specific distributors or regional partners.

Croma's aesthetics portfolio is often a strong fit for clinics that:

• Emphasize natural, skin-quality-driven outcomes over dramatic volumization alone.
• Want an integrated system that spans HA fillers, regenerative boosters, and threads.
• Serve patient populations receptive to European-manufactured, CE-marked technologies.

Alternatives To Croma Aesthetic Products

Alternatives in the HA filler space include large portfolios such as Allergan's JUVÉDERM family and Galderma's Restylane line, which offer extensive viscosity and indication options backed by long-term global clinical data and strong brand recognition. In the regenerative arena, polylactic acid and CaHA biostimulators such as Sculptra and Radiesse, along with PRP and exosome-based injectables, offer distinct mechanisms for collagen induction and skin-quality improvement.

Many clinics carry a mix of brands to accommodate patient familiarity and specific rheologic or biostimulatory preferences, while balancing wholesale pricing and manufacturer support programs.

How To Choose The Right Croma Products

• Step 1: Define your clinical niche by clarifying whether your practice focuses on contouring, skin quality, or regenerative aesthetics, which will determine your mix of Saypha, PhilArt, and PN-based boosters.
• Step 2: Model your economics by mapping expected session pricing in your geography against wholesale costs, recognizing that HA fillers often retail between $600 and $1,200 per syringe with margins driven by volume-based discounts.
• Step 3: Evaluate patient demand and educational needs, particularly if your patient base is unfamiliar with polynucleotides or European filler brands, and prepare messaging that highlights safety, natural results, and clinical backing.

Clinics can also leverage educational content, before-and-after imagery, and manufacturer or distributor training to help injectors master product selection, injection techniques, and combination protocols for optimal outcomes.

Buy Croma Aesthetics Products With Portrait Care

A profitable Croma strategy depends on structured purchasing and reliable supply, just as it does for Merz or other aesthetic brands. Portrait Care's provider network supports ordering of medical supplies, products, and equipment at competitive prices through a centralized platform, helping clinics manage cost, logistics, and inventory in one place.

• Tiered and volume-aware pricing structures help practices protect margins as procedure volumes grow.
• Online ordering and inventory visibility reduce stockouts and make it easier to align Saypha, PhilArt, and regenerative product stock with booking trends.
• Access to a curated vendor directory and med spa partners via pages such as the Portrait Care provider directory supports networking and operational benchmarking across markets.

To learn more about sourcing Croma Pharma's aesthetics portfolio and optimizing your injectable and regenerative product mix, speak to Portrait Care today.